渡邊研究室

東京大学分子細胞生物学研究所 染色体動態研究分野

Laboratory of Chromosome Dynamics Institute of Molecular and Cellular Biosciences

 

        Goto Y., Yamagishi Y., Shintomi-Kawamura M., Abe M., Tanno Y. & Watanabe Y.

            Pds5 regulates sister chromatid cohesion and chromosome bi-orientation

            through a conserved protein interaction module.

            Curr. Biol. 27, 1005-1012 (2017)


        Ishiguro, K. and Watanabe, Y.

            The cohesion REC8 prevents illegitimate inter-sister synaptonemal complex assembly

            EMBO rep. 17: 783-784 (2016)


        Akera, T. and Watanabe, Y.

            The spindle assembly checkpoint promotes chromosome bi-orientation; a novel Mad1 role in chromosome alignment.

            Cell Cycle 15:4, 493–497 (2016)


        Stanzione, M., Baumann, M., Papanikos, F., Dereli, I., Lange, J., Ramlal, A., Trankner, D., Shibuya, H.,

        de Massy, B., Watanabe, Y., Jasin, M., Keeney, S., and *Toth, A.

            Meiotic DNA break formation requires the unsynapsed chromosome axis-binding protein IHO1 (CCDC36) in mice.

            Nat. Cell Biol. 17, 783-784 (2016)


        Mikolcevic, M., Michitaka, I., Shibuya H., del Barco Barrantes, I., Igea1, A., Suja, J., Shackleton, S.,

        Watanabe, Y. and Nebreda, A.

            Essential role of the Cdk2 activator RingoA in meiotic telomere tethering to the nuclear envelope.

            Nat. Commun. 7:11084 (2016)


        Shibuya H, Hernández-Hernández A, Morimoto A, Negishi L, Höög C, Watanabe Y.

            MAJIN Links Telomeric DNA to the Nuclear Membrane by Exchanging Telomere Cap

            Cell 163, 1252–1266 (2015)


     Tanno Y, Susumu H, Kawamura M, Sugimura H, Honda T, Watanabe Y.

            The inner centromere-shugoshin network prevents chromosomal instability.

            Science 349, 1237-1240 (2015)


        Akera T,Goto Y,Sato M, Yamamoto M, Watanabe Y.

            Mad1 promotes chromosome congression by anchoring a kinesin motor to the kinetochore.

            Nat Cell Biol. 17, 1124-1133 (2015)


        Sakuno T, Watanabe Y.

            Phosphorylation of Cohesin Rec11/SA3 by Casein Kinase 1 Promotes Homologous Recombination

            by Assembling the Meiotic Chromosome Axis.

            Dev Cell 32, 220-230 (2015)


        Kim J*, Ishiguro K*, Nambu A, Akiyoshi B, Yokobayashi S, Kagami A, Ishiguro T,

        Pendas AM, Takeda N, Sakakibara Y, Kitajima TS, Tanno Y, Sakuno T, Watanabe Y.

            Meikin is a conserved regulator of meiosis-I-specific kinetochore function.

            Nature 517, 466–471 (2015)


        Shibuya H, Morimoto A, Watanabe Y

            The dissection of meiotic chromosome movement in mice using an in vivo electroporation technique.

            PLoS Genet. 10, e1004821 (2014)


        Shibuya H. , Watanabe Y.

            The meiosis-specific modification of mammalian telomeres.

            Cell cycle. 13, 2024-2028 (2014)


        Ishiguro KI, Kim J, Shibuya H, Hernández-Hernández A, Suzuki A, Fukagawa T, Shioi G, Kiyonari H ,

        Li XC, Schimenti J, Höög C, Watanabe Y.

            Meiosis-specific cohesin mediates homolog recognition in mouse spermatocytes.

            Genes Dev. 28, 594-607 (2014)


        Shibuya H, Ishiguro K, Watanabe Y.

            The TRF1-binding protein TERB1 promotes chromosome movement and telomere rigidity in meiosis.

            Nat Cell Biol. 16, 145-156 (2014)


        Yamagishi Y, Sakuno T, Goto Y, Watanabe Y..

            Kinetochore composition and its function: lessons from yeasts.

            FEMS Microbiol Rev.  38, 185-200 (2013)


        Yamagishi Y and Watanabe Y.

            Cell Biology: Cohesin Ring Exit Gate Revealed (Dispatch)

            Curr. Biol. 22, R958-960 (2012)


        Yamashita A, Kariyazono R, and Watanabe Y.

            Meiotic pairing by non-coding RNA? (Opinion)

            EMBO Rep. 13, 766 (2012)


        Morimoto A*, Shibuya H*, Zhu X, Kim J, Ishiguro K, Han M, Watanabe Y.

            A conserved KASH domain protein associates with telomeres, SUN1, and dynactin during mammalian meiosis.

            J Cell Biol. 198, 165-172 (2012)


        Yamagishi Y, Yang CH, Tanno Y, Watanabe Y.

            MPS1/Mph1 phosphorylates the kinetochore protein KNL1/Spc7 to recruit SAC components.

            Nat Cell Biol. 14, 746–752 (2012)


        Watanabe Y.

         Geometry and force behind kinetochore orientation: lessons from meiosis.

            Nat Rev Mol Cell Biol. 13, 370-82 (2012)


        Kagami A, Sakuno T, Yamagishi Y, Ishiguro T, Tsukahara T, Shirahige K, Tanaka K, Watanabe Y.

         Acetylation regulates monopolar attachment at multiple levels during meiosis I in fission yeast.

            EMBO Rep. 12, 1189-95 (2011)


        Sakuno T, Tanaka K, Hauf S, Watanabe Y.

           Repositioning of aurora B promoted by chiasmata ensures sister chromatid mono-orientation in meiosis I.

           Dev Cell 21, 534-45.(2011)


        Tada K, Susumu H, Sakuno T, Watanabe Y.

           Condensin association with histone H2A shapes mitotic chromosomes.

           Nature 474, 477-483 (2011)


        Ishiguro, K., Kim, J., Fujiyama-Nakamura, S., Kato, S. and Watanabe, Y.
   A new meiosis-specific cohesin complex implicated in the cohesin code for homologous pairing.
   
EMBO rep.12, 267-275 (2011)

  Yamagishi, Y.*, Honda, T.*, Tanno Y. and Watanabe Y.
   Two histone marks establish the inner centromere and chromosome bi-orientation.
   
Science 330, 239-243 (2010)

  Tsukahara, T., Tanno, Y. and Watanabe Y.
   Phosphorylation of the CPC by Cdk1 promotes chromosome bi-orientation.
   
Nature 467, 719-723 (2010)

  Tanno Y., Kitajima T.S., Honda, T., Ando Y., Ishiguro K.-i. and Watanabe Y.
   Phosphorylation of mammalian Sgo2 by Aurora B recruits PP2A and MCAK to centromeres.
   
Genes Dev. 22, 2639-2644 (2010)

  Lister L.M., Kouznetsova A., Hyslop L.A., Kalleas D., Pace S.L., Barel J.C., Nathan A., Floros V., Adelfalk C.,
  Watanabe Y., Jessberger R., Kirkwood T.B., Hoog C. and Herbert M.
   Age-related meiotic segregation errors in Mammalian oocytes are preceded by depletion of cohesin and Sgo2.
   
Curr Biol. 20, 1511-21 (2010)


        Watanabe, Y.

           Temporal and spatial regulation of targeting Aurora B to the inner centromere.

           Cold Spring Harb Symp Quant Biol. 75:419-423 (2010)


  Ishiguro, T., Tanaka, K., Sakuno, T. and Watanabe, Y.
   Shugoshin-PP2A counteracts Casein Kinase 1-dependent cleavage of Rec8 by separase.
   
Nat Cell Biol. 12, 500-506 (2010)

  Kawashima, S.A., Yamagishi, Y.*, Honda, T.*, Ishiguro, K and Watanabe, Y.
   Phosphorylation of H2A by Bub1 prevents chromosomal instability through localizing shugoshin.
   
Science 327, 172-177 (2010)

  Takemoto, A., Maeshima, K., Ikehara, T., Yamaguchi, K., Murayama, A., Imamura, S., Imamoto, N., Yokoyama, S.,
  Hirano, T., Watanabe, Y., Hanaoka, F., Yanagisawa, J., and Kimura, K.
   The chromosomal association of condensin II is regulated by a noncatalytic function of PP2A.
   
Nat. Struct. Mol. Biol. 15, 1302-1308 (2009)

  Tanaka, K., Chang, HL., Kagami, A.and Watanabe, Y.
   CENP-C functions as a scaffold for effectors with essential kinetochore functions in mitosis and meiosis.
   
Dev Cell. 17, 334-343 (2009)

  Sakuno, T., Tada, K.and Watanabe, Y.
   Kinetochore geometry defined by cohesion within the centromere.
   
Nature 458, 852-858 (2009)

  Omran, H.*, Kobayashi, D.*, Olbrich, H.*, Tsukahara, T.*, Loges, N. T., Hagiwara, H., Zhang, Q., Leblond, G.,
  O’Toole, E., Hara, C., Mizuno, H., Kawano, H., Fliegauf, M., Yagi, T., Koshida, S., Miyawaki, A., Zentgraf, H.,
  Seithe, H., Reinhardt, R., Watanabe Y., Kamiya, R., Mitchel, D. R. and Takeda, H.
   Ktu/PF13 is required for cytoplasmic pre-assembly of axonemal dyneins.
   
Nature 456, 611-616 (2008)

  Tanaka, K.and Watanabe, Y.
   Chromatid cohesion:acethylation joins the sisters. (Dispatch)
   
Curr. Biol. 18, R917-R919 (2008)

  Eot-Houllier, G., Fulcrand, G., Watanabe, Y., Magnaghi-Jaulin, L. and Jaulin, C.
   Histone deacetylase 3 is required for centromeric H3K4 deacetylation and sister chromatid cohesion.
   
Genes Dev 22, 2639-2644 (2008)

  Yamagishi, Y., Sakuno, T., Shimura, M., and Watanabe, Y.
    Heterochromatin links to centromeric protection by recruiting shugoshin
   
Nature 455, 251-255 (2008)

  *Lee, J., *Kitajima, T.S., Tanno, Y., Yoshida, K., Morita, T., Miyano, T, Miyake, M., and Watanabe, Y.
    Unified mode of centromeric protection by shugoshin in mammalian oocytes and somatic cells.
   
Nat Cell Biol. 10, 42-52 (2008)

  Hauf, S., Biswas A., Langegger, M., Kawashima, S.A., Tsukahara, T., and Watanabe, Y.
    Aurora controls sister kinetochore mono-orientation and homolog bi-orientation in meiosis-I.
   
EMBO J. 26, 4475-4486 (2007)

  Kawashima, S.A., Tsukahara, T., Langegger, M., Hauf, S., Kitajima, T.S. and Watanabe, Y.
    Shugoshin enables tension-generating attachment of kinetochores by loading Aurora to centromeres.
   
Genes Dev. 21, 420-435 (2007)

  Watanabe, Y. A one-sided view of kinetochore attachment in meiosis .(Review)
   
Cell 126, 1030-2(2006)

  Harigaya, Y., Tanaka, H., Yamanaka, S., Tanaka, K., Watanabe, Y., Tsutsumi, C.,
    Chikashige, Y., Hiraoka, Y., Yamashita, A. and Yamamoto, M.
    Selective elimination of messenger RNA prevents an incidence of untimely meiosis.
   
Nature 442, 45-50 (2006)

  Kitajima TS, Sakuno T, Ishiguro K, Iemura S, Natsume T, Kawashima SA, Watanabe Y.
    Shugoshin collaborates with protein phosphatase 2A to protect cohesin.
   
Nature. 441, 46-52 (2006)

  Yokobayashi S,Watanabe, Y.
   The kinetochore protein Moa1 enables cohesion-mediated monopolar attachment at meiosis I.
   
Cell. 123, 803-817 (2005)

  Watanabe, Y. Shugoshin: guardian spirit at the centromere.(review)
   
Curr Opin Cell Biol. 17, 590-595(2005)

  Watanabe, Y. Sister chromatid cohesion along arms and at centromeres. (review)
   
Trends Genet. 21, 405-412 (2005)

  Watanabe, Y. The importance of being Smc5/6.(news & views)
   
Nat Cell Biol 7, 329-331 (2005)

  Kitajima TS, Hauf S, Ohsugi M, Yamamoto T, Watanabe Y.
   Human Bub1 defines the persistent cohesion site along the mitotic chromosome
   by affecting Shugoshin localization.
Curr. Biol. 15, 353-359 (2005)


  Hauf, S. and Watanabe, Y. Kinetochore orientation in mitosis and meiosis. (review)
   
Cell 119, 317-327 (2004)

   Lengronne, A., Katou, Y., Mori, S., Yokobayashi, S., Kelly, G., Itoh, T., Watanabe, Y.,
   Shirahige, K. and Uhlmann, F. Cohesin relocation from sites of chromosomal loading
   to places of convergent transcription.
Nature 430, 573-578 (2004)

  
  Kitajima, T. S., Kawashima, S. A. and Watanabe, Y. The conserved kinetochore protein
   shugoshin protects centromeric cohesion during meiosis.
Nature 427, 510-7 (2004).

   Kitajima, T. S., Miyazaki, Y., Yamamoto, M. and Watanabe, Y. Rec8 cleavage by separase is
   required for meiotic nuclear divisions in fission yeast.
EMBO J. 22, 5643-53 (2003).

  Watanabe, Y. Monopolar attachment by Polo. (commentary)
  
Nat Cell Biol. 5, 379-382 (2003).

   *Kitajima, T. S., *Yokobayashi, S., Yamamoto, M., and Watanabe, Y. Distinct cohesin complexes
   organize meiotic chromosome domains.
Science 300, 1152-5 (2003).

   Yokobayashi, S., Yamamoto, M., and Watanabe, Y. Cohesins determine the attachment
   manner of kinetochores to spindle microtubules at meiosis I in fission yeast.
Mol Cell Biol 23,
3965-73 (2003).

   *Nonaka, N., *Kitajima, T., Yokobayashi, S., Xiao, G., Yamamoto, M., Grewal, S, and Watanabe, Y.
   Recruitment of cohesin to heterochromatic regions by Swi6/HP1 in fission yeast.
  
Nat Cell Biol 4, 89-93. (2002).

  Watanabe, Y., Yokobayashi, S., Yamamoto, M., and Nurse, P. Pre-meiotic S-phase is linked to
   reductional chromosome segregation and recombination.
Nature 409, 359 - 363 (2001).

   Watanabe, Y., and Nurse, P. Cohesin Rec8 is required for reductional chromosome
   segregation at meiosis.
Nature 400, 461 - 464 (1999).

   Cooper, J. P., Watanabe, Y., and Nurse, P. Fission yeast Taz1 protein is required for
   meiotic telomere clustering and recombination.
Nature 392, 828-831(1998).

   Yamashita, A., Watanabe, Y., Nukina, N., and Yamamoto, M. RNA-assisted nuclear transport of the meiotic
    regulator Mei2p in fission yeast.
Cell 95, 115-123 (1998).

   Watanabe, Y., Shinozaki-Yabana, S., Chikashige, Y., Hiraoka, Y., and Yamamoto, M.
   Phosphorylation of RNA-binding protein controls cell cycle switch from mitotic to meiotic in fission yeast.
   
Nature 386, 187-190 (1997).

   Watanabe, Y., and Yamamoto, M. S.pombe mei2+ encodes an RNA-binding protein essential for
   premeiotic DNA synthesis and meiosis I, which cooperates with a novel RNA species meiRNA.
   
Cell 78, 487-498 (1994).

  * = contributed equally

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