東京大学定量生命科学研究所先端定量生命科学研究部門

蛋白質複合体解析研究分野

(放射光分野融合国際卓越拠点)

〒113-0032 東京都文京区弥生1−1−1 東京大学定量生命科学研究所 本館3F 306

Tel 03-5841-7807, Fax 03-5841-0706

 

主な研究成果:


Structural insights into modulation and selectivity of transsynaptic neurexin–LRRTM interaction.

Nature Communications, 9, 3964 (2018)


Structural insights into ubiquitin phosphorylation by PINK1.

Scientific Reports, 8, 10382 (2018)


Structural basis of epilepsy-related ligand–receptor complex LGI1–ADAM22.

Nature Communications, 9, 1546 (2018)


Structural basis of trans-synaptic interactions between PTPδ and SALMs for inducing synapse formation.

Nature Communications, 9, 269 (2018)


Structural insights into two distinct binding modules for Lys63-linked polyubiquitin chains in RNF168.

Nature Communications, 9, 170 (2018)


Structural basis for specific cleavage of Lys6-linked polyubiquitin chains by USP30.

Nature Structural & Molecular Biology, 24, 911-919 (2017)


Distinct roles for the N- and C-terminal regions of M-Sec in plasma membrane deformation during tunneling nanotube formation.

Scientific Reports, 6, 33458 (2016)


Structure of Slitrk2–PTPδ complex reveals mechanisms for splicing-dependent trans-synaptic adhesion.

Scientific Reports, 5, 9686 (2015)


Mechanisms of splicing-dependent trans-synaptic adhesion by PTPδ–IL1RAPL1/IL-1RAcP for synaptic differentiation.

Nature Communications, 6, 6926 (2015)


Structures of CYLD USP with Met1- or Lys63-linked diubiquitin reveal mechanisms for dual specificity.

Nature Structural & Molecular Biology, 22, 222-229  (2015)


Structure of TCR and antigen complexes at an immunodominant CTL epitope in HIV-1 infection.

Scientific Reports, 3, 3097 (2013)


Specific recognition of linear ubiquitin chains by the Npl4 zinc finger (NZF) domain of the HOIL1-1L subunit of the linear ubiquitin chain assembly complex.

Proc. Natl. Acad. Sci. U. S. A. 108, 20520-20525 (2011)


Structural basis for the Rho- and phosphoinositide-dependent localization of the exocyst subunit Sec3.

Nature Structural & Molecular Biology 17, 180-186 (2010)


Structural basis for specific recognition of Lys 63-linked polyubiquitin chains by NZF domains of TAB2 and TAB3.

EMBO Journal, 28, 3903-3909 (2009)


Structural basis for specific recognition of Lys 63-linked polyubiquitin chains by tandem UIMs of RAP80. EMBO Journal, 28,  2461-2468 (2009)


Structural basis for specific cleavage of Lys 63-linked polyubiquitin chains.

Nature, 455, 358-362 (2008)



学内共同研究:


定量生命科学研究所,医科学研究所,医学系研究科,薬学系研究科,農学系研究科,理学系研究科,総合文化研究科