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研究発表
Research Presentation

論文

2019

MZB1 promotes the secretion of J-chain-containing dimeric IgA and is critical for the suppression of gut inflammation.
Xiong E, Li Y, Min Q, Cui C, Hong R, Lai N, Wang Y, Sun J, Matsumoto R, Takahashi D, Hase K, Shinkura R, Tsubata T, Wang JY.
Proc Natl Acad Sci U S A. 2019 Jul 2;116(27):13480-13489. doi: 10.1073/pnas.1904204116.

2017

Accelerated Systemic Autoimmunity in the Absence of Somatic Hypermutation in 564Igi: A Mouse Model of Systemic Lupus with Knocked-In Heavy and Light Chain Genes.
McDonald G, Medina CO, Pilichowska M, Kearney JF, Shinkura R, Selsing E, Wortis HH, Honjo T, Imanishi-Kari T.
Front Immunol. 2017 Sep 13;8:1094. doi: 10.3389/fimmu.2017.01094. eCollection 2017.

2017

Decreased Taxon-Specific IgA Response in Relation to the Changes of Gut Microbiota Composition in the Elderly.
Sugahara H, Okai S, Odamaki T, Wong CB, Kato K, Mitsuyama E, Xiao JZ, Shinkura R.
Front Microbiol. 2017 Sep 12;8:1757. doi: 10.3389/fmicb.2017.01757. eCollection 2017.

2017

Intestinal IgA as a modulator of the gut microbiota.
Okai S, Usui F, Ohta M, Mori H, Kurokawa K, Matsumoto S, Kato T, Miyauchi E, Ohno H, Shinkura R.
Gut Microbes. 2017 Sep 3;8(5):486-492. doi: 10.1080/19490976.2017.1310357.

2016

High-affinity monoclonal IgA regulates gut microbiota and prevents colitis in mice.Okai S, Usui F, Yokota S, Hori-I Y, Hasegawa M, Nakamura T, Kurosawa M, Okada S, Yamamoto K, Nishiyama E, Mori H, Yamada T, Kurokawa K, Matsumoto S, Nanno M, Naito T, Watanabe Y, Kato T, Miyauchi E, Ohno H, Shinkura R.
Nat Microbiol. 2016 Jul 4;1(9):16103. doi: 10.1038/nmicrobiol.2016.103.

2015

A novel germline mutation in a patient with nevoid basal cell cartinoma syndrome showing cystic lesion in the lung.Miyata R, Kurosawa M, Sato M, Kono T, Takubo Y, Okai S, Yamada K, Shinkura R, Date H, Matsuda F. Hum Genome Var. 2015 Jun 11;2:15014. doi: 10.1038/hgv.2015.14.

2011

Myelin basic protein as anovel genetic risk factor in rheumatoid arthritis?a genome-wide study combined with immunological analyses.
Terao C, Ohmura K, Katayama M, Takahashi M, Kokubo M, Diop G, Toda Y, Yamamoto N; Human Disease Genomics Working Group.; Rheumatoid Arthritis (RA) Clinical and Genetic Study Consortium., Shinkura R, Shimizu M, Gut I, Heath S, Melchers I, Manabe T, Lathrop M, Mimori T, Yamada R, Matsuda F.
PLoS One. 2011;6(6):e20457. doi: 10.1371/journal.pone.0020457.

Histone chaperone Spt6 is required for class switch recombination but not somatic hypermutation.
Okazaki IM, Okawa K, Kobayashi M, Yoshikawa K, Kawamoto S, Nagaoka H, Shinkura R, Kitawaki Y, Taniguchi H, Natsume T, Iemura S, Honjo T.
Proc Natl Acad Sci U S A. 2011 May 10;108(19):7920-5. doi: 10.1073/pnas.1104423108.

Mice carrying a knock-in mutation of Aicda resulting in a defect in somatic hypermutationhave impaired gut homeostasis and compromised mucosal defense.
Wei M*, Shinkura R*, Doi Y, Maruya M, Fagarasan S, Honjo T. (*equal contributors) Nat Immunol. Mar;12(3):264-70, 2011.

Histone chaperone Spt6 is required for class switch recombination but not somatic hypermutation.
Okazaki IM, Okawa K, Kobayashi M, Yoshikawa K, Kawamoto S, Nagaoka H. Shinkura R, Kitawaki Y, Taniguchi H, Natsume T, Iemura S, Honjo T.
Proc Natl Acad Sci U S A. May 10;108(19):7920-5, 2011.

2009

The C-terminal Region of activation-induced cytidine deaminase is responsible for a recombination function other than DNA cleavage in class switch recombination.
Doi T, Kato LS, Ito S, Shinkura R, Wei M, Nagaoka H, Wang J and Honjo T.
Proc Natl Acad Sci U S A 106, 2758-2763, 2009.

Apex2 is required for efficient somatic hypermutation but not for class switch recombination of immunoglobulin genes. (*equal contributors) Sabouri Z*, Okazaki IM*, Shinkura R*, Begum N, Nagaoka H, Tsuchimoto D, Nakabeppu Y, Honjo T. Int Immunol. Aug;21(8):947-55, 2009.

B cell-specific and stimulation-responsive enhancers derepress the Aicda gene by overcoming the effects of silencers.
Tran TH, Nakata M, Begum NA, Shinkura R, *Honjo T and Nagaoka H.
Nat Immunol. Feb;11(2):148-54,2009.

AID-induced decrease in topoisomerase 1 induces DNA structural alterlation and DNA cleavage for class switch recombination. Kobayashi M, Aida M, Nagaoka H, Begum NA, Kitawaki Y, Nakata M, Stanlie A, Doi T, Kato L, Okazaki IM, Shinkura R, Muramatsu M, Kinoshita K and Honjo T.
Proc Natl Acad Sci U S A Dec 29;106(52):22375-80, 2009.

2008

Dissociation of in vitro DNA deamination activity and physiological functionsof AID mutants. (*equal contributors) Shivarov, V*, Shinkura R* Honjo T.
Proc Natl Acad Sci U S A 105, 15866-15871, 2008.

2007

Requirement of non-canonical activity of uracil DNA glycosylase for class switch recombination. Begum NA, Izumi N, Nishikori M, Nagaoka H,
Shinkura R and Honjo T. J Biol Chem 282, 731-742, 2007.

Msx2-interacting nuclear target protein (Mint) deficiency reveals negative regulation of early thymocyte differentiation by Notch/RBP-J signaling.
Tsuji M, Shinkura R, Kuroda K, Yabe D and Honjo T.
Proc Natl Acad Sci U S A, 104, 1610-1615, 2007.

2004

Growth retardation, early death, andDNA repair defectsin mice deficient for the nucleotide excision repair enzyme XPF. Tian M, Shinkura R, Shinkura N, and Alt FW.
Mol Cell Biol 24(3), 1200-1205, 2004.

Activation-induced cytidine deaminase shuttles between nucleus and cytoplasm like apolipoprotein B mRNA editing catalytic polypeptide 1.
Ito S, Nagaoka H, Shinkura R, Begum NA, Muramatsu M, Nakata M, andHonjo T.
Proc Natl Acad Sci U S A 101(7), 1975-1980, 2004.

Deficiency in the nuclease activity of xeroderma pigmentosum G in mice leads to hypersensitivity to UV irradiation. Tian M, Jones DA, Smith M, Shinkura R, and Alt FW. Mol Cell Biol 24(6), 2237-2242, 2004.

Separate domains of AID are required for somatic hypermutation and class-switch recombination. Shinkura R, Ito S, Begum NA, Nagaoka H, Muramatsu M, Kinoshita K, Sakakibara Y, Hijikata H and Hono T. Nat Immunol 5(7), 707-712, 2004.

De novo protein synthesis is required for activation-induced cytidine deaminase-dependent DNA cleavage in immuno-globulin class switch recombination. Begum NA, Kinoshita K, Muramatsu M, Nagaoka H, Shinkura R, and Honjo T. Proc Natl Acad Sci U S A 101(35), 13003-13007, 2004.

Uracil DNA glycosylase activity is dispensable for immunoglobulin class switch. Begum NA, Kinoshita K, Kakazu N, Muramatsu M, Nagaoka H, Shinkura R, Biniszkiewicz D, Boyer LA, Jaenisch R, and Honjo T.
Science 305(5687), 1160-1163, 2004.

2003

The influence of transcriptional orientation on endogenous switch region function. Shinkura R*, Tian M*, Smith M, ChuaK, Fujiwara Y and Alt FW. (*equal contributors) Nat Immunol 4(5), 435-441, 2003.

WAVE2 deficiency reveals distinct roles in embryogenesis and Rac-mediated actin-based motility. Yan C, Martinez-Quiles N, Eden S, Shibata T, Takashima F, Shinkura R, Fujiwara Y, Bronson R, Snapper SB, Kirschner MW, Geha R, Rosen FS, and Alt FW. EMBO J 22(14), 3602-3612, 2003.

2000

Lineage-restricted function of nuclear factor kappaB-inducing kinase (NIK) in transducing signals via CD40. Garceau N, Kosaka Y, Masters S, Hambor J, Shinkura R, Honjo T and Noelle RJ. J Exp Med 191(2), 381-386, 2000.

Alymphoplasia (aly)-type nuclear factor kappaB-inducing kinase (NIK) causes defects in secondary lymphoid tissue chemokine receptor signaling and homing of peritoneal cells to the gut-associated lymphatic tissue system. Fagarasan S, Shinkura R, Kamata T, Nogaki F, Ikuta K, Tashiro K and Honjo T. J Exp Med 191(9), 1477-1486, 2000.

1999

Alymphoplasia is caused by a point mutation in the mouse gene encoding Nf-kapp b-inducing kinase. (* equal contributors) Shinkura R*, Kitada K*, Matsuda F, Tashiro K, Ikuta K, Suzuki M, Kogishi K, Serikawa T, Honjo T. Nat Genet 22(1), 74-77, 1999.

IL-7 receptor alpha+ CD3(-) cells in the embryonic intestine induces the organizing center of Peyer's patches. Yoshida H, Honda K, Shinkura R, Adachi S, Nishikawa S, Maki K, Ikuta K and Nishikawa SI. Int Immunol 11(5), 643-655, 1999.

1996

Defects of somatic hypermutation and class switching in alymphoplasia (aly) mutant mice. Shinkura R, Matsuda F, Sakiyama T, Tsubata T, Hiai H, Paumen M, Miyawaki S and Honjo T. Int Immunol 8(7), 1067-1075, 1996.

Autoimmune disease of exocrine organs in immunodeficient alymphoplasia mice: a spontaneous model for Sjogren's syndrome. Tsubata R, Tsubata T, Hiai H, Shinkura R, Matsumura R, Sumida T, Miyawaki S, Ishida H, Kumagai S, Nakao K and Honjo T. Eur J Immunol 26(11), 2742-2748, 1996.

総説

IgA抗体による腸管粘膜面の免疫監視機構
石垣佳祐、新藏礼子
実験医学, 36(18), 3059-3063, 2018


腸管IgA抗体による腸内細菌制御機構
新藏礼子
医学のあゆみ, 2018年11月,44-48


腸管IgA抗体による腸内細菌制御
岡井晋作、新藏礼子
実験医学, 35(7), 1084-1089, 2017


高親和性モノクローナルIgAはマウスの腸内細菌叢を改善し大腸炎を予防する
岡井晋作、新藏礼子
実験医学, 34(19), 3185-3188, 2016


’’微生物と人類の共存’’をゲノムの視点から
新藏礼子、他共著
生物の科学, 71(1), 77-85, 2016


IgA抗体による腸内細菌の制御機構
新藏礼子
医学のあゆみ, 2015年5月, 375-380


免疫グロブリンの体細胞突然変異・クラススイッチとAIDおよびその関連分子
新藏礼子
臨床免疫・アレルギー科(54巻・1号), 72-79


腸管免疫の恒常性における免疫グロブリン遺伝子の体細胞突然変異の重要性
新藏礼子
臨床免疫・アレルギー科(58巻・4号), 361-367

特許

免疫調節剤 特願2016-160573 新藏礼子、山本 晃大

モノクローナルIgA抗体の製造方法 特許第5916946号(日本) PCT/JP2014/056216新藏礼子

ポリペプチド 特願2015-117946 新藏礼子、岡井晋作、臼井文人