Okazaki Lab

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Welcome to Okazaki Lab.


News

Jan 15, 2020
Shimizu K et al. Molecular Cell (2019) was highlighted by ACIR.
Journal site


Jan 8, 2020
Shimizu K, Sugiura D, Okazaki IM, Maruhashi T, Takegami Y, Cheng C, Ozaki S, and Okazaki T
PD-1 imposes qualitative control of cellular transcriptomes in response to T cell activation.
Molecular Cell, Epub ahead of print
Journal site


Dec 13, 2019
Joint seminar with Prof. Shohei Hori (Graduate School of Pharmaceutical Sciences).
Dr. Dietmar Zehn, Technical University of Munich, “InTOXication causes T-cell exhaustion in chronic infection.”
Dr. Pere Santamaria, University of Calgary, “Peptide-MHC-based nanomedicines for the treatment of autoimmune disease: engineering, mechanisms and diseases.”

Dec 12, 2019
Daisuke Sugiura received the Young Investigator Award of the Japanese Society for Immunology.

Dec 10, 2019
Daisuke Sugiura and Takumi Maruhashi received the Tokushima University President Award for young scientists.

Nov 13, 2019
Maeda N, Maruhashi T, Sugiura D, Shimizu K, Okazaki IM, and Okazaki T.
Glucocorticoids potentiate the inhibitory capacity of PD-1 by up-regulating its expression on T cells.
Journal of Biological Chemistry, Epup ahead of print
Journal site


Nov, 2019
Natsumi Maeda received the Kouraku Award.

Nov 1, 2019
Okazaki Lab has moved to the Institute for Quantitative Biosciences, The University of Tokyo.

Jul, 2019
Natsumi Maeda received the Yoshimitsu Otsuka Scholarship.

Jul 2, 2019
Okamura H, Okazaki IM, Shimizu K, Maruhashi T, Sugiura D, Mizuno R, and Okazaki T.
PD-1 aborts the activation trajectory of autoreactive CD8 T cells to prohibit their acquisition of effector functions.
Journal of Autoimmunity, Epub ahead of print
Journal site


Jul, 2019
Sugiura D et al. Science, 364:558 (2019) was highlighted by Cancer Discovery.

Journal site


May 20, 2019
Sugiura D et al. Science, 364:558 (2019) was highlighted by Nature Immunology.

Journal site


May 8, 2019
Sugiura D et al. Science, 364:558 (2019) was highlighted by ACIR.

Journal site


Apr 18, 2019
Sugiura D, Maruhashi T, Okazaki IM, Shimizu K, Maeda TK, Takemoto T, and Okazaki T.
Restriction of PD-1 function by cis-PD-L1/CD80 interactions is required for optimal T cell responses.
Science, 364(6440):558-566 (2019)
Journal site


Apr, 2018
Natsumi Maeda received the Katsunuma Scholarship.

Mar 29, 2019
Mizuno R, Sugiura D, Shimizu K, Maruhashi T, Watada M, Okazaki IM, and Okazaki T.
PD-1 primarily targets TCR signal in the inhibition of functional T cell activation.
Frontiers in Immunology, 10:630, 2019
Journal site


Mar 6, 2019
Maeda TK et al., J Biol Chem, 294(15): 6017-6026 was highlighted by ACIR
Journal site


Feb, 2019
Two medical students (Jun Ikubo and Taisuke Yamamoto) have joined our laboratory.

Feb 13, 2019
Maeda TK, Sugiura D, Okazaki IM, Maruhashi T, and Okazaki T.
Atypical motifs in the cytoplasmic region of the inhibitory immune co-receptor LAG-3 inhibit T cell activation.
Journal of Biological Chemistry, 294(15): 6017-6026
PubMed


Feb 13, 2019
Mizuno R, Maruhashi T, Sugiura D, Shimizu K, Watada M, Okazaki IM, and Okazaki T.
PD-1 efficiently inhibits T cell activation even in the presence of co-stimulation through CD27 and GITR.
Biochemical and Biophysical Research Communications, 511(3):491-497, 2019
PubMed


Jan, 2019
Takumi Maruhashi was awarded the Oka Prize.

Nov 16, 2018
News & Views on Maruhashi et al. (Nature Immunology, 19:1415-1426, 2018) by Drs. Lui and Davis. "LAG-3: a very singular immune checkpoint"
Journal site


Oct 22, 2019
Maruhashi T, Okazaki IM, Sugiura D, Takahashi S, Maeda TK, Shimizu K, and Okazaki T.
LAG-3 inhibits the activation of CD4+ T cells that recognize stable pMHCII through its conformation-dependent recognition of pMHCII.
Nature Immunology, 19:1415-1426, 2018
PubMed


Oct 1, 2018
Dr. Tasuku Honjo, the mentor of Okazaki IM and Okazaki T, has been announced to receive the Nobel Prize in physiology or medicine.

Jun, 2018
A research project "Singularity biology" has been started. This project is supported by the Grant-in-Aid by the Japan Society for the Promotion of Science for Scientific Research on Innovative Areas.
http://singularity-bio.jp/eng/

Jun 30, 2018
Reina Mizuno received the best presentation award in the 17th Shikoku Immunology Forum.

Apr, 2017
Natsumi Maeda received the Katsunuma Scholarship.

Mar, 2018
Ryuki Abiru joined our group.
Two medical students (Riko Okano and Mitsuki Shimizu) have joined our laboratory.

Feb, 2018
Reina Mizuno was awarded the
Kouraku Prize
.