東京大学 定量生命科学研究所 病態発生制御研究分野についての紹介です。

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業績

2020

  • KimC., Noda T., Kim H., Kim G., Park S., Na Y., Oura S., Shimada K., Bang I., Ahn J., Kim Y., Oh S., Choi H., Kim J., Jung I., Lee H., Okada Y., Ikawa M., Baek S. (2020) PHF7 Modulates BRDT Stability and Histone-to-Protamine Exchange during Spermiogenesis.Cell Rep. 32(4):107950. PMID: 32726616 DOI: 10.1016/j.celrep.2020.107950
  • Tsuboyama K., Osaki T., Matsuura-Suzuki E., Kozuka-Hata H., Okada Y., Oyama M., Ikeuchi Y., Iwasaki S., Tomari Y. (2020) A widespread family of heat-resistant obscure (Hero) proteins protect against protein instability and aggregation. PLoS Biol 18(3):e3000632. DOI: 10.1371/journal.pbio.3000632

    • 2019

  • Makino Y., Niels H J, Yokota N., Moritz J R, Akiyama H., Shirahige K., Okada Y. (2019) Single cell RNA-sequencing identified Dec2 as a suppressive factor for spermatogonial differentiation by inhibiting Sohlh1 expression. Scientific Reports. Apr 15;9(1):6063. PMID: 30988352 DOI: 10.1038/s41598-019-42578-z

    • 2018

  • Kojima K., Nakamura H., Komeya M., Yamanaka H., Makino Y., Okada Y., Akiyama H., Torikai N., Sato T., Fujii T., Kimura H., Ogawa T. (2018) Neonatal testis growth recreated in vitro by two-dimensional organ spreading. Biotechnol Bioeng. [Epub ahead of print]　PMID : 30144353　DOI : 10.1002/bit.26822
  • Yamaguchi K., Hada M., Fukuda Y, Inoue E, Katou Y., Shirahige K., Okada Y. (2018) Re-evaluating the localization of sperm-retained histones revealed the modification-dependent accumulation in specific genome regions. Cell Reports. 23(13):3920-3932.　PMID : 29949774　DOI : 10.1016/j.celrep.2018.05.094
  • 野老美紀子、山縣一夫、岡田由紀 (2018)「哺乳類の精子形成から受精卵へ」、実験医学増刊号「染色体を解く」（平野達也、胡桃坂仁志　編)、羊土社

    • 2017

  • Hada M, Kim J, Inoue E, Fukuda Y, Tanaka H, Watanabe Y, Okada Y. (2017) TH2A is phosphorylated at meiotic centromere by Haspin. Chromosoma. 126(6):769-780.　PMID : 28803373　DOI : 10.1007/s00412-017-0638-5
  • Aoshima K, Kimura T, Okada Y. (2017) Use of Histone K-M Mutants for the Analysis of Transcriptional Regulation in Mouse Zygotes. Methods Mol Biol.,1605:259-270.　PMID : 28456971　DOI : 10.1007/978-1-4939-6988-3_18
  • Hada M., Masuda K., Yamaguchi K., Shirahige K., Okada Y. (2017) Identification of a variant-specific phosphorylation of TH2A during spermiogenesis. Sci Rep. 7:46228.　PMID : 28387373　PMCID : PMC5384234　DOI : 10.1038/srep46228
  • Miyazaki S., Kim J., Yamagishi Y., Ishiguro T., Okada Y., Tanno Y., Sakuno T., Watanabe Y. (2017) Meikin-associated polo-like kinase specifies Bub1 distribution in meiosis I. Genes Cells. 22(6):552-567.　PMID : 28497540　DOI : 10.1111/gtc.12496
  • Ueda J., Harada A., Urahama T., Machida S., Maehara K., Hada M., Makino Y., Nogami J., Horikoshi N., Osakabe A., Taguchi H., Tanaka H., Tachiwana H., Yao T., Yamada M., Iwamoto T., Isotani A., Ikawa M., Tachibana T., Okada Y., Kimura H., Ohkawa Y., Kurumizaka H., Yamagata K. (2017) Testis-Specific Histone Variant H3t Gene Is Essential for Entry into Spermatogenesis. Cell Reports, 18(3):593-600.　PMID : 28099840　DOI : 10.1016/j.celrep.2016.12.065
  • Okada Y, Yamaguchi K. (2017) Epigenetic modifications and reprogramming in paternal pronucleus: sperm, preimplantation embryo, and beyond. Cell Mol Life Sci. 74(11):1957-1967.　PMID : 28050628 　DOI : 10.1007/s00018-016-2447-z
  • 浦聖恵、岡田由紀 (2017)「ヒストンバリアント」「遺伝子発現制御機構～クロマチン、転写制御、エピジェネティクス～」（田村隆明・浦聖恵　編著)、東京化学同人

    • 2016

  • Izumi K, Brett M, Nishi E, Drunat S, Tan ES, Fujiki K, Lebon S, Cham B, Masuda K, Arakawa M, Jacquinet A, Yamazumi Y, Chen ST, Verloes A, Okada Y, Katou Y, Nakamura T, Akiyama T, Gressens P, Foo R, Passemard S, Tan EC, El Ghouzzi V, Shirahige K. (2016) ARCN1 Mutations Cause a Recognizable Craniofacial Syndrome Due to COPI-Mediated Transport Defects. Am J Hum Genet. 99:451-9.　PMID : 27476655　PMCID : PMC4974084 　DOI : 10.1016/j.ajhg.2016.06.011

    • 2015

  • Okada Y, Aoshima K. (2015) KM mutant highlights enhancers in minor ZGA. Cell Cycle. 14(16):2541-2.　PMID : 26065875　PMCID : PMC4614105　DOI: 10.1080/15384101.2015.1060774.
  • Aoshima K., Inoue E, Sawa H., Okada Y. (2015) Paternal H3K4 methylation is required for minor zygotic gene activation and early mouse embryonic development. EMBO Rep. 16(7):803-12.　PMID : 25925669　PMCID : PMC4515120　DOI : 10.15252/embr.201439700.

    • 2014

  • Makino Y, Inoue E, Hada M, Aoshima K, Kitano S, Miyachi H, Okada Y. (2014) Generation of a dual-color reporter mouse line to monitor spermatogenesis in vivo. Frontiers in Cell and Developmental Biology. 23;2:30.　PMID : 25364737　PMCID : PMC4206980　DOI : 10.3389/fcell.2014.00030.
  • 羽田政司、岡田由紀. (2014)「ヒストン制御とエピジェネティクス」、生体の科学　第65巻第6号

    • 2013

  • Suzuki T, Orba Y, Makino Y, Okada Y, Sunden Y, Hasegawa H, Hall WW, Sawa H. (2013) Viroporin activity of the JC polyomavirus is regulated by interactions with the adaptor protein complex 3. Proc Natl Acad Sci U S A. 110(46):18668.　PMID : 24167297　PMCID : PMC3832026　DOI : 10.1073/pnas.1311457110
  • Aoshima K, Baba A, Makino Y, Okada Y. (2013) Establishment of Alternative Culture Method for Spermatogonial Stem Cells Using Knockout Serum Replacement. PLOS ONE. 8(10):e77715.　PMID : 24204931　PMCID : PMC3810131　DOI : 10.1371/journal.pone.0077715
  • 青島圭佑、岡田由紀. (2013)「マウス受精卵前核期におけるクロマチンダイナミクス」、生化学誌 第85巻 第4号、公益社団法人日本生化学会

    • 2012

  • 牧野吉倫、岡田由紀. (2012)「精子形成のエピジェネティック制御機構」、実験医学30 (18)、羊土社

    • ～2011

  • ＜原著論文＞
  • Yamagata K, Okada Y. (2011) Understanding paternal genome demethylation through live-cell imaging and siRNA. Cell Mol Life Sci. 2011 68:1669-79.　PMID : 21234640　DOI : 10.1007/s00018-010-0623-0
  • Suzuki T, Orba Y, Okada Y, Sunden Y, Kimura T, Tanaka S, Nagashima K, Hall WW, Sawa H. (2010) The human polyoma JC virus agnoprotein acts as a viroporin. PLoS Pathog. 6:e1000801.　PMID : 20300659　PMCID : PMC2837404　DOI : 10.1371/journal.ppat.1000801
  • Okada Y, Yamagata K, Hong K, Wakayama T, Zhang Y. (2010) A role for the elongator complex in zygotic paternal genome demethylation. Nature. 463:554-8.　PMID : 20054296　PMCID : PMC2834414　DOI : 10.1038/nature08732
  • Okada Y, Tateishi K, Zhang Y. (2010) Histone demethylase JHDM2A is involved in male infertility and obesity. J Androl. 31:75-8. Review.　PMID : 19875498　PMCID : PMC4096721　DOI : 10.2164/jandrol.109.008052
  • Tateishi K, Okada Y, Kallin EM, Zhang Y. (2009) Role of Jhdm2a in regulating metabolic gene expression and obesity resistance. Nature. 458:757-61.　PMID : 19194461　PMCID : PMC4085783　DOI : 10.1038/nature07777
  • Okada Y, Scott G, Ray MK, Mishina Y, Zhang Y. (2007) Histone demethylase JHDM2A is critical for Tnp1 and Prm1 transcription and spermatogenesis. Nature. 450:119-23.　PMID : 17943087　DOI : 10.1038/nature06236
  • Sunden Y, Semba S, Suzuki T, Okada Y, Orba Y, Nagashima K, Umemura T, Sawa H. (2007) DDX1 promotes proliferation of the JC virus through transactivation of its promoter. Microbiol Immunol. 51(3):339-47.　PMID : 17380054
  • Sunden Y, Semba S, Suzuki T, Okada Y, Orba Y, Nagashima K, Umemura T, Sawa H. (2007) Identification of DDX1 as a JC virus transcriptional control region-binding protein. Microbiol Immunol. 51(3):327-37.　PMID : 17380053
  • Okada Y, Jiang Q, Lemieux M, Jeannotte L, Su L, Zhang Y. (2006) Leukemic transformation by CALM-AF10 involves upregulation of Hoxa5 by hDOT1L. Nat. Cell. Biol. 8:1017-24.　PMID : 16921363　PMCID : PMC4425349 　DOI : 10.1038/ncb1464
  • Okada Y, Feng Q, Lin Y, Jiang Q, Li Y, Coffield VM, Su L, Xu G, Zhang Y. (2005) hDOT1L links histone methylation to leukemogenesis. Cell. 121:167-78.　PMID : 15851025　DOI : 10.1016/j.cell.2005.02.020
  • Suzuki T, Okada Y, Semba S, Orba Y, Yamanouchi S, Endo S, Tanaka S, Fujita T, Kuroda S, Nagashima K, Sawa H. (2005) Identification of FEZ1 as a protein that interacts with JC virus agnoprotein and microtubules: role of agnoprotein-induced dissociation of FEZ1 from microtubules in viral propagation. J Biol Chem. 280:24948-56.　PMID : 15843383　DOI : 10.1074/jbc.M411499200
  • Okada Y*, Suzuki T*, Sunden Y, Orba Y, Kose S, Imamoto N, Takahashi H, Tanaka S, Hall WW, Nagashima K, Sawa H. (2005) Dissociation of heterochromatin protein 1 from lamin B receptor induced by human polyomavirus agnoprotein: role in nuclear egress of viral particles. EMBO Rep. 6:452-7. (*Okada Y and Suzuki T were equally contributed).　PMID : 15864296　PMCID : PMC1299312　DOI : 10.1038/sj.embor.7400406
  • Qu Q, Sawa H, Suzuki T, Semba S, Henmi C, Okada Y, Tsuda M, Tanaka S, Atwood WJ, Nagashima K. (2004) Nuclear entry mechanism of the human polyomavirus JC virus-like particle: role of importins and the nuclear pore complex. J. Biol. Chem. 279:27735-42.　PMID : 15069063　DOI : 10.1074/jbc.M310827200
  • Endo S, Okada Y, Orba Y, Nishihara H, Tanaka S, Nagashima K, Sawa H.(2003) JC virus agnoprotein colocalizes with tubulin. J. Neurovirol.;9 Suppl 1:10-4.　PMID : 12709865　DOI : 10.1080/13550280390195333
  • Takai H, Naka K, Okada Y, Watanabe M, Harada N, Saito S, Anderson CW, Appella E, Nakanishi M, Suzuki H, Nagashima K, Sawa H, Ikeda K, Motoyama N. (2002) Chk2-deficient mice exhibit radioresistance and defective p53-mediated transcription. EMBO J. 21(19):5195-205.　PMID : 12356735　PMCID : PMC129029
  • Yoshida H, Okada Y, Kinoshita N, Hara H, Sasaki M, Sawa H, Nagashima K, Mak TW, Ikeda K, Motoyama N. (2002) Differential requirement for Apaf1 and Bcl-X(L) in the regulation of programmed cell death during development. Cell Death Differ. 9(11):1273-6.　PMID : 12404127　DOI : 10.1038/sj.cdd.4401128
  • Kobayashi Y*, Watanabe M*, Okada Y*, Sawa H, Takai H, Nakanishi M, Kawase Y, Suzuki H, Nagashima K, Ikeda K, Motoyama N. (2002) Hydrocephalus, situs inversus, chronic sinusitis, and male infertility in DNA polymerase λ-deficient mice: Possible implications for the pathogenesis of immotile cilia syndrome. Mol. Cell. Biol. 8: 2769-76. (*Kobayashi Y, Watanabe M, Okada Y were equally contributed).　PMID : 11909969　PMCID : PMC133740
  • Okada Y, Sawa H, Endo S, Orba Y, Umemura T, Nishihara H, Stan AC, Tanaka S, and Nagashima K. (2002) Expression of JC virus (JCV) agnoprotein in progressive multifocal leukoencephalopathy (PML) brain. Acta Neuropathogica. 104: 130-6.　PMID : 12111355　DOI : 10.1007/s00401-002-0526-8
  • Okada Y, Endo S, Takahashi H, Sawa H, Umemura T, Nagashima K. (2001) Distribution and function of JCV agnoprotein. J. Neurovirol. 7: 302-306.　PMID : 11517407　DOI : 10.1080/13550280152537148
  • Safak M, Barrucco R, Darbinyan A, Okada Y, Nagashima K, Khalili K. (2001) Interaction of JC virus agno protein with T antigen modulates transcription and replication of the viral genome in glial cells. J Virol. 75(3):1476-86.　PMID : 11152520　PMCID : PMC114053　DOI : 10.1128/JVI.75.3.1476-1486.2001
  • Suzuki S, Sawa H, Komagome R, Orba Y, Yamada M, Okada Y, Ishida Y, Nishihara H, Tanaka S, Nagashima K. (2001) Broad distribution of the JC virus receptor contrasts with a marked cellular restriction of virus replication. Send to Virology. 286(1):100-12.　PMID : 11448163　DOI : 10.1006/viro.2001.0972
  • Kimura T, Mitsui I, Okada Y, Furuya T, Ochiai K, Umemura T, Itakura C. (2001) Distribution of rabbit haemorrhagic disease virus RNA in experimentally infected rabbits. J Comp Pathol. 124(2-3):134-41.　PMID : 11222010　DOI : 10.1053/jcpa.2000.0440
  • Yamashita S, Mochizuki N, Ohba Y, Tobiume M, Okada Y, Sawa H, Nagashima K, Matsuda M. (2000) CalDAG-GEFIII activation of Ras, R-Ras, and Rap1. J. Biol. Chem. 275:25488-25493.　PMID : 10835426　DOI : 10.1074/jbc.M003414200
  • Okada Y, Sawa H, Tanaka S, Takada A, Suzuki S, Hasegawa H, Umemura T, Fujisawa J-I, Tanaka Y, Hall WW, Nagashima K. (2000) Transcriptional activation of JC virus (JCV) by human T-lymphotropic virus type I (HTLV-I) Tax protein in human neuronal cell lines. J. Biol. Chem. 275, 17016-17023.　PMID : 10828075
  • ＜邦文著書＞
  • 岡田由紀、Yi Zhang. (2008)「精子形成におけるヒストン脱メチル化酵素Jhdm2aの役割」、実験医学26(9) 羊土社
  • 岡田由紀、Yi Zhang. (2006)「ヒストンメチル化と白血病発症」、血液フロンティア、16(1), 医薬ジャーナル社

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